If you occasionally forget to take a dose, take your next dose the next day at the usual time. The dose is based on your child's age, going up to a maximum of 40mg. For the first 12 months on this medicine, you'll be offered a couple of routine tests to make sure your liver is working OK. It's unusual to have any side effects. -Patients should be instructed to read the patient labeling. Simvastatin can be taken by adults and children over the age of 10 years. -Take orally once a day in the evening Children and elderly. Your doctor will find the right statin and dose for you, depending on your medical history, cholesterol level and the other medicines you take. Simvastatin 10 mg tablets can be sold to the public to reduce risk of first coronary event in individuals at moderate risk of coronary heart disease (approx. Author information: (1)Division of Cardiology and Clinical Pharmacology, Taipei Medical College, Taipei Municipal Wan-Fang Hospital, Taiwan. Ask your doctor or pharmacist for advice if you're unsure how much to take. Simvastatin is safe to take for a long time. You can report any suspected side effect to the UK safety scheme. Statins have been used for nearly 30 years to lower cholesterol. If you decide to take a CoQ10 supplement, tell your doctor or pharmacist. It's unusual to have any side effects. Severe renal dysfunction: Initial dose: 5 mg orally once a day; monitor closely, Active liver disease or unexplained transaminase elevations: Contraindicated If you stop taking simvastatin without starting a different treatment, your cholesterol level may rise again. -Take on an empty stomach If you want to stop taking your medicine, it's important to find another way to lower your cholesterol. Keep … Never take extra doses. -Active liver disease, which may include unexplained persistent elevations in hepatic transaminase levels Oral Suspension: These are not all the side effects of simvastatin. 10–15 % risk of major event in 10 years), max. Simvastatin seems to be a very safe medicine and it's unusual to have side effects. -High-risk patients may initiate at 40 mg orally once a day Use: To reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia (HoFH) as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable. If both drugs are given concurrently, advise people to report any unexplained muscle pain, tenderness, or weakness. Initial dose: 10 to 20 mg orally once a day It's also taken to prevent heart disease, including heart attacks and strokes. -Obtain liver function tests prior to initiating therapy and as clinically indicated If you're at high risk of developing type 2 diabetes, taking statins may slightly increase this risk. Simvastatin seems to be a very safe medicine. -Coadministration with Amiodarone, Amlodipine, or Ranolazine: Simvastatin dose should not exceed 20 mg/day --LDL cholesterol remains 190 mg/dL or greater, OR --LDL cholesterol remains 160 mg/dL or greater and there is a positive family history of premature cardiovascular disease (CVD), OR two or more other CVD risk factors are present, Mild to moderate renal dysfunction: No adjustment recommended A dose of 80 mg should be restricted to patients who have been prescribed a statin medicine. However, stopping simvastatin may cause your cholesterol to rise. Findings In this secondary analysis of the randomized clinical Improved Reduction of Outcomes: Vytorin Efficacy International Trial, which enrolled 18 144 patients, greater reduction of … Some medicines don't mix well with simvastatin, including: If you're taking simvastatin and need to take one of these medicines, your doctor may: St John's wort, a herbal medicine taken for depression, reduces the amount of simvastatin in your blood, so it doesn't work as well. Report any unexplained muscle pain, tenderness or weakness to a doctor straight away. To evaluate the short‐term safety and efficacy of low‐dose (10 mg) simvastatin in hypercholesterolemic, hypertensive elderly Chinese patients receiving antihypertensive treatment, a randomized, double‐blind, placebo‐controlled, 3 Chan P(1), Huang TY, Tomlinson B, Lee C, Lee YS. Sometimes the side effects that people report aren't related to their -Lactation Coadministration of niacin (≥1 g) in patients of Chinese descent. Is it safe to take simvastatin for a long time? They may recommend taking a different statin. Simvastatin seems to be a very safe medicine. It's not known if simvastatin passes into breast milk, but it may cause problems for your baby. How does it compare with other medicines for high cholesterol? There's no firm evidence to suggest that taking simvastatin will reduce fertility in either men or women. Danazol — rhabdomyolysis has been reported with concurrent use. for 12 months or more) without evidence of muscle toxicity -If a patient on simvastatin 80 mg/day needs to initiate an interacting drug (one that will increase simvastatin concentrations); simvastatin should be switched to an alternative statin with less potential for drug-drug interaction. My elderly aunt just had to stop simvastatin due to sever back and leg pain. Talk to your doctor if you're planning to become pregnant. -Shake well for at least 20 seconds before measuring dose Conclusions: Infections in older adults are associated with prolonged, impaired neutrophil migration, potentially contributing to poor outcomes. Short-term safety and efficacy of low-dose simvastatin in elderly patients with hypertensive hypercholesterolemia and fasting hyperinsulinemia. Typical starting dosage: Simvastatin is often started at 10–20 mg per day. Reducing your cholesterol may mean you don't need to be -Oral Suspension: Store at room temperature (68F to 77F [20C to 25C]); Protect from heat; do not freeze or refrigerate; Use within 30 days after opening -Substantial alcohol ingestion and/or past history of liver disease: Use with caution Yes, you can drink alcohol while taking simvastatin. -Patients should be advised to adhere to a diet and exercise program. Simvastatin is also called Zocor and Simvador. Restricted Use (due to myopathy risk): 80 mg/day should only be used in patients who have been taking this drug chronically (e.g. -Simvastatin 80 mg dose should only be used in patients who have taken this dose chronically (e.g., for 12 months or more) without evidence of muscle toxicity -Coadministration with Niacin 1 g/day or more: Not recommended for Chinese patients Simvastatin belongs to a group of medicines called statins.